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This gene encodes a synaptic vesicle membrane protein The encoded protein is thought to function as a calcium sensor in vesicular trafficking and exocytosis Mutations in this gene are associated with myasthenic syndrome presynaptic congenital
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Image Search Results
Journal: eLife
Article Title: GABA A presynaptic inhibition regulates the gain and kinetics of retinal output neurons
doi: 10.7554/eLife.60994
Figure Lengend Snippet: ( A ) GABA A α1 immunolabeling (yellow) and Synaptotagmin2 (Syt2) immunolabeling (red) of OFF CBC terminals in KO retina shows robust GABA A α1 immunoreactivity in the OFF sublamina. IPL: inner plexiform layer. ( B ) Average excitatory synaptic currents across OFF alpha transient retinal GCs (RGCs) in response to 10 ms flash of 100% contrast at a background luminance of 1000R*/S cone/s. ( C ) Bar graph showing quantification of the peak excitatory current response in ( B ) for OFF alpha transient RGCs in WT (mean ± sem = 239.2 ± 23.75 pA) and KO (mean ± sem = 226.4 ± 28.5 pA) retina. ( D ) GABA A β2/3 receptor signal (yellow) within calbindin positive AC and GC processes across the ON lamina of the IPL in WT and KO retina. Scale bar = 20 μm. ( E ) Quantification of the percentage occupancy of GABA A β2/3 signal within calbindin AC and GC processes in WT (mean ± sem = 3.2 ± 0.3) and KO (mean ± sem = 2.8 ± 0.7) retinas (n = 3 retinas).
Article Snippet: Antibody ,
Techniques: Immunolabeling
Journal: eLife
Article Title: GABA A presynaptic inhibition regulates the gain and kinetics of retinal output neurons
doi: 10.7554/eLife.60994
Figure Lengend Snippet:
Article Snippet: Antibody ,
Techniques: Transgenic Assay, Expressing, Generated, Plasmid Preparation, Software